Following a coordinated effort of 65 authors from 20 countries, the European Academy of Allergy and Clinical Immunology (EAACI) has recently published a comprehensive guide that contains up-to-date knowledge on molecular allergology. The book covers all types of allergies: food allergy; anaphylaxis; allergic rhinitis; allergic conjunctivitis; asthma; atopic dermatitis; occupational allergies; and insect venom hypersensitivity.
The information in the guide is presented in three main parts:
- Part A introduces allergen molecules, families, composition of extracts, databases and diagnostic IgE, skin and basophil tests. Singleplex and multiplex IgE assays with components improve both sensitivity for low-abundance allergens and analytical specificity; IgE to individual allergens can yield information on clinical risks and distinguish cross-reactivity from true primary sensitization.
- Part B discusses the clinical and molecular aspects of IgE-mediated allergies to foods, inhalants, and venom.
- Part C covers protein families containing ubiquitous, highly cross-reactive panallergens from plant and animal sources and explains their diagnostic and clinical utility.
- The book also contains a list of 100 important allergen molecules.
The guide explains in detail how to apply molecular testing in allergy diagnosis using emerging technologies to help improve patient care. With all of this knowledge now held in one central place, it is intended to evolve to a web-based repository that can be updated on a regular basis with the latest advances in the field of allergology. The current edition is available for download from the EAACI website.
Reference: Matricardi et al. 2016. Pediatric Allergy and Immunology. Vol. 27 Suppl 23 pp. 1-250. Doi: 10.1111/pai.12563.