Amish children in northern Indiana, USA, have been found to have remarkably low rates of allergies and asthma. Researchers attribute this to early exposure to farm dust and microbes which strengthens the immune system.
In the studies, only 7 per cent of Amish children showed sensitivity to common allergens compared to over 50 per cent of the general U.S. population. Unlike some other farming communities, Amish children are exposed to barns and animals from infancy, resulting in a microbial-rich environment that appears to protect against allergic diseases.
Examination of Amish household dust showed it contains seven times more microbial content than Hutterite homes. Researchers then identified proteins in the dust that deliver microbial molecules to the respiratory tract, regulating immune responses and preventing inflammation. When Amish dust was administered to mice by inhalation under experimental conditions, fewer allergic symptoms were observed.
The findings support a ‘microbial hypothesis’ where beneficial bacteria play a key role in immune development. Scientists hope to develop treatments such as probiotics that mimic these protective exposures, potentially revolutionising allergy prevention for children worldwide.
See The Washington Post for full reporting.
