In a study that screened 40 different flavonoids, kaempferol was identified as the most effective at modulating immune responses and reducing inflammation in allergic reactions. Kaempferol is a naturally occurring compound found in foods like kale, spinach, beans, tea, and broccoli.
The Japanese research team behind the study conducted experiments on mice induced with allergies. They found that kaempferol significantly alleviated symptoms, indicating its potential as a natural treatment for food allergies.
Kaempferol produces an anti-inflammatory effect by promoting regulatory T-cell development through increased expression of the enzyme RADLH2 (retinaldehyde dehydrogenase 2) in dendritic cells. These specialised cells convert retinal from vitamin A into retinoic acid, fostering the development of regulatory T-cells that suppress the immune response observed in allergies.
Further studies are required, particularly with human cells, to confirm the latest findings and explore how kaempferol could potentially be used as an allergy medicine. In the meantime, the study authors suggest that when included as part of a healthy, balanced diet, flavonoids may reduce inflammation and symptoms of autoimmune diseases caused or aggravated by excessive immune response.
Reference: Takahashi M, et al., Kaempferol Exerts Anti-Inflammatory Effects by Accelerating Treg Development via Aryl Hydrocarbon Receptor-Mediated and PU.1/IRF4-Dependent Transactivation of the Aldh1a2/Raldh2 Gene in Dendritic Cells. Allergy. 2024 DOI: 10.1111/all.16410.
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